Can I make .22 HOT load with Aguila Super Colibri bullets?

Sounds like you could be making a hand grenade out of a firearm. Smokeless powder is susseptable to high pressures. I could be way over pressure for the firearm and make it self disemble. If you want a really great .22 round, go with the .22 Mag or .223 if you will settle for a center fire. A .223 has about 10x the energy of a .22 lr.